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The science and practice of human immunology

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The science and practice of human immunology

Welcome to the CIS WEBbook of Biologic Therapies!

The Clinical Immunology Society maintains the WEBbook of Biologic Therapies as a service to the Society members and the medical community in general. The WEBbook lists certain targeted biologics that are FDA approved in the United States and gives their names (generic, brand, and others), molecular target, molecular structure, licensed indications, manufacturer, distributor, and date of first FDA approval. A compound may be found in the Search/Index tab, listed alphabetically by its generic and brand names; or in the Table of Compounds, listed alphabetically by generic name only. Selecting a compound’s name in either location will link to a short summary discussion of that agent, including a list of a few important references, along with their URLs, and the package insert URL. A brief section entitled Nomenclature explains the semantic logic behind the choice of the generic names.

The WEBbook includes agents that were selected as:

  1. Recombinant non-physiologic proteins, i.e., monoclonal antibodies and receptor constructs;
  2. Certain physiologic proteins of particular interest to clinical immunologists.  Such proteins may  either be produced by recombinant technology or purified from human sources;
  3. Immunologically modified autologous cells;
  4. Radiochemical or toxin conjugates of #1 or #2.

The WEBbook does not include:

  1. Many purified proteins;
  2. Most blood products, including IgG in its various forms;
  3. Many cell, tissue and organ grafts, including stem cells;
  4. Vaccines against microbial agents;
  5. Allergenic extracts;
  6. Antisera

In addition, the WEBbook does not include agents that are not FDA approved, even if they are approved in other countries. It also avoids discussion of non-approved ("off label") uses of approved compounds, even if these have become generally accepted in the medical community.


The information contained in the WEBbook is intended for educational purposes, and should not be relied on for decisions related to immediate patient care (see Full Disclaimer).  The Website Medical Editor welcomes suggestions, corrections or comments at webbook@clinimmsoc.org.


The date of update of individual entries is given with the summary discussion of that entry.  The CIS Communications Committee is responsible for updates to the WEBbook of Biologics.