Clinical Immunology Society

Cetuximab

Brand Name

Erbitux

Other Names

None

Molecular Target

EGF (Epidermal Growth Factor) receptor

Molecular Structure

chimeric monoclonal antibody

Licensed Indication, Major Target Diseases

metastatic colorectal cancer; head and neck cancer 

Manufacturer/Distributor

Imclone & Bristol-Meyers Squibb (North America);
Merck KGaA (other areas)

References

 Source  Link  Revision Date
 Access Date
Erbitux Prescribing Information
http://www.bms.com/products/data/index.html
2007-November
2008-June-02
Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol. 2004 Apr 1;22(7):1201-8
http://www.ncbi.nlm.nih.gov/pubmed/14993230
 2008-May-29
Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, Chau I, Van Cutsem E. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004 Jul 22;351(4):337-45
http://content.nejm.org/cgi/content/...ract/351/4/337

 2008-May-29
Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS, Baselga J, Youssoufian H, Amellal N, Rowinsky EK, Ang KK. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006 Feb 9;354(6):567-78
http://content.nejm.org/cgi/content/...ract/354/6/567

 2008-May-29
Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A, Hamilton A, Pan D, Schrag D, Schwartz L, Klimstra DS, Fridman D, Kelsen DP, Saltz LB. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol. 2005 Mar 20;23(9):1803-10
http://www.ncbi.nlm.nih.gov/pubmed/15677699

 2008-May-29
Robert F, Ezekiel MP, Spencer SA, Meredith RF, Bonner JA, Khazaeli MB, Saleh MN, Carey D, LoBuglio AF, Wheeler RH, Cooper MR, Waksal HW. Phase I study of anti--epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J Clin Oncol. 2001 Jul 1;19(13):3234-43
http://www.ncbi.nlm.nih.gov/pubmed/11432891
 2008-May-29
Matar P, Rojo F, Cassia R, Moreno-Bueno G, Di Cosimo S, Tabernero J, Guzmán M, Rodriguez S, Arribas J, Palacios J, Baselga J. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin Cancer Res. 2004 Oct 1;10(19):6487-501
http://clincancerres.aacrjournals.or...ull/10/19/6487

 2008-May-29
Lièvre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, Côté JF, Tomasic G, Penna C, Ducreux M, Rougier P, Penault-Llorca F, Laurent-Puig P. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006 Apr 15;66(8):3992-5
http://www.ncbi.nlm.nih.gov/pubmed/18202412

 2008-May-29
Baselga J. The EGFR as a target for anticancer therapy--focus on cetuximab. Eur J Cancer. 2001 Sep;37 Suppl 4:S16-22
http://www.ncbi.nlm.nih.gov/pubmed/11597400

 2008-May-29
Xiong HQ, Rosenberg A, LoBuglio A, Schmidt W, Wolff RA, Deutsch J, Needle M, Abbruzzese JL. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J Clin Oncol. 2004 Jul 1;22(13):2610-6
http://www.ncbi.nlm.nih.gov/pubmed/15226328
 2008-May-29
Raben D, Helfrich B, Chan DC, Ciardiello F, Zhao L, Franklin W, Barón AE, Zeng C, Johnson TK, Bunn PA Jr. The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):795-805
http://clincancerres.aacrjournals.or.../full/11/2/795

 2008-May-29
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