Eculizumab is a monoclonal antibody that inhibits terminal complement activation by binding to complement protein C5. It is indicated for the treatment of paroxysmal nocturnal hemaglobinuria to reduce hemolysis.
This drug is sold under the tradename "Soliris" and is produced by Alexion pharmaceuticals. Prescribing information states that eculizumab is contraindicated in patients with unresolved Neisseria meningitidis infection or in patients who have not been vaccinated against Neisseria meningitidis. Caution is advised in patients with any systemic infection.
| Source | Link | Revision Date | Access Date |
| Alexion | http://www.soliris.net/ | 2008-Jan | 2008-May-29 |
| Brodsky RA. Advances in the diagnosis and therapy of paroxysmal nocturnal hemoglobinuria. Blood Rev. 2008 Mar;22(2):65-74 | http://www.pubmedcentral.nih.gov/art...?artid=2290854 | 2008-Apr | 2008-June-06 |
| Hillmen P, Young NS et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006 Sep 21;355(12):1233-43 | http://content.nejm.org/cgi/content/full/355/12/1233 | 2006-Sep | 2008-Jun-06 |
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