Clinical Immunology Society

Tositumomab I131

Brand Name

Bexxar

Molecular Target

CD20

Molecular Structure

murine monoclonal; covalently bound to Iodine-131

Licensed Indication, Major Target Diseases

non-Hodgkins Lymphoma (CD20 positive, follicular) which is refractory to rituximab and relapsed following chemotherapy.

Manufacturer/Distributor

GlaxoSmithKline

References

 Source  Link  Revision Date
 Access Date
Bexxar Prescribing Information
http://www.bexxar.com/
2005-October
2008-June-02
Jacene HA, Filice R, Kasecamp W, Wahl RL. Comparison of 90Y-ibritumomab tiuxetan and 131I-tositumomab in clinical practice. J Nucl Med. 2007 Nov;48(11):1767-76
http://www.ncbi.nlm.nih.gov/pubmed/17942813
 2008-May-29
Kaminski MS, Estes J, Zasadny KR, Francis IR, Ross CW, Tuck M, Regan D, Fisher S, Gutierrez J, Kroll S, Stagg R, Tidmarsh G, Wahl RL. Radioimmunotherapy with iodine (131)I tositumomab for relapsed or refractory B-cell non-Hodgkin lymphoma: updated results and long-term follow-up of the University of Michigan experience. Blood. 2000 Aug 15;96(4):1259-66
http://bloodjournal.hematologylibrar...full/96/4/1259

2008-May-29
Vose JM, Wahl RL, Saleh M, Rohatiner AZ, Knox SJ, Radford JA, Zelenetz AD, Tidmarsh GF, Stagg RJ, Kaminski MS. Multicenter phase II study of iodine-131 tositumomab for chemotherapy-relapsed/refractory low-grade and transformed low-grade B-cell non-Hodgkin's lymphomas. J Clin Oncol. 2000 Mar;18(6):1316-23
http://www.ncbi.nlm.nih.gov/pubmed/10715303

2008-May-29
Kaminski MS, Zelenetz AD, Press OW, Saleh M, Leonard J, Fehrenbacher L, Lister TA, Stagg RJ, Tidmarsh GF, Kroll S, Wahl RL, Knox SJ, Vose JM. Pivotal study of iodine I 131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphomas. J Clin Oncol. 2001 Oct 1;19(19):3918-28
http://www.ncbi.nlm.nih.gov/pubmed/11579112

2008-May-29
Horning SJ, Younes A, Jain V, Kroll S, Lucas J, Podoloff D, Goris M. Efficacy and safety of tositumomab and iodine-131 tositumomab (Bexxar) in B-cell lymphoma, progressive after rituximab. J Clin Oncol. 2005 Feb 1;23(4):712-9
http://www.ncbi.nlm.nih.gov/pubmed/15613695
2008-May-29
Kaminski MS, Tuck M, Estes J, Kolstad A, Ross CW, Zasadny K, Regan D, Kison P, Fisher S, Kroll S, Wahl RL. 131I-tositumomab therapy as initial treatment for follicular lymphoma. N Engl J Med. 2005 Feb 3;352(5):441-9
http://content.nejm.org/cgi/content/full/352/5/441

2008-May-29
Vose JM, Bierman PJ, Enke C, Hankins J, Bociek G, Lynch JC, Armitage JO. Phase I trial of iodine-131 tositumomab with high-dose chemotherapy and autologous stem-cell transplantation for relapsed non-Hodgkin's lymphoma. J Clin Oncol. 2005 Jan 20;23(3):461-7
http://www.ncbi.nlm.nih.gov/pubmed/15534357

2008-May-29
Wahl RL. The clinical importance of dosimetry in radioimmunotherapy with tositumomab and iodine I 131 tositumomab. Semin Oncol. 2003 Apr;30(2 Suppl 4):31-8
http://www.ncbi.nlm.nih.gov/pubmed/12728405

2008-May-29
Davis TA, Kaminski MS, Leonard JP, Hsu FJ, Wilkinson M, Zelenetz A, Wahl RL, Kroll S, Coleman M, Goris M, Levy R, Knox SJ. The radioisotope contributes significantly to the activity of radioimmunotherapy. Clin Cancer Res. 2004 Dec 1;10(23):7792-8
http://clincancerres.aacrjournals.or...ull/10/23/7792

2008-May-29
Leonard JP, Coleman M, Kostakoglu L, Chadburn A, Cesarman E, Furman RR, Schuster MW, Niesvizky R, Muss D, Fiore J, Kroll S, Tidmarsh G, Vallabhajosula S, Goldsmith SJ. Abbreviated chemotherapy with fludarabine followed by tositumomab and iodine I 131 tositumomab for untreated follicular lymphoma. J Clin Oncol. 2005 Aug 20;23(24):5696-704
http://www.ncbi.nlm.nih.gov/pubmed/16110029

2008-May-29
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