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WEBbook of Biologic Therapies > Therapeutic Fusion Proteins

Therapeutic Fusion Proteins

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Nomenclature

There is a method to the nomenclature:

1. Syllable before the structure syllable:
"immune system" = -li- or -lim-
2. Syllable before "mab":
chimeric: -xi_
humanized -zu-
fully human -u-
murine -mo-

Thus:
chimeric human/mouse antibodies are ximabs,
humanized antibodies are zumabs,
fully human antibodies are umabs,
murines are  momabs.

Chemical or Common Name Brand Name Other Names Molecular Target Molecular Structure Licensed Indication, Major Target Diseases
Manufacturer and/or Distributor
Abatacept Orencia CTLA4Ig, BMS-188667
B7-1 (CD80),
B7-2 (CD86)
CTLA4-Human IgG1 Fusion protein Rheumatoid Arthritis,
Juvenile Rheumatoid Arthritis
Bristol Myers Squibb
Alefacept Amevive BG 9273
CD2 LFA-3-IgG1 Fc fusion protein moderate to severe, chronic plaque psoriasis Astellas Pharma
Biogen IDEC
Denileukin diftitox
ONTAK

IL-2 Receptor
recombinant fusion protein expressing amino acid residues of diphtheria toxin fragment A & B, followed by the sequence for IL-2
recurrent CD25 positive, cutaneous T-cell lymphoma
Eisai
Etanercept Enbrel
TNFα and TNFβ TNFR-IgG1 Fc fusion protein Rheumatoid Arthritis;
Juvenile Idiopathic Arthritis;
psoriatic arthritis;
ankylosing spondylitis;
plaque psoriasis
Amgen
Wyeth
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