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WEBbook of Biologic Therapies > In-Vivo Imaging Antibodies

In-Vivo Imaging Antibodies

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Nomenclature

There is a method to the nomenclature:

1. Syllable before the structure syllable:

"immune system" = -li- or -lim-
2. Syllable before "mab":
chimeric: -xi_
humanized -zu-
fully human -u-
murine -mo-

Thus:
chimeric human/mouse antibodies are ximabs,
humanized antibodies are zumabs,
fully human antibodies are umabs,
murines are  momabs.


Chemical or Common Name Brand Name Other Names Molecular Target Molecular Structure Licensed Indication, Major Target Diseases
Manufacturer and/or Distributor
Capromab pendetide Prostascint 7E11-C5.3
Prostate Specific Membrane Antigen (PSMA)
murine monoclonal IgG1κ, indium-111 labeled Diagnostic imaging of metastatic prostate cancer in newly diagnosed, high risk patients
Cytogen
Sulesomab Fab' fragment
Leukoscan IMMU-MN3 CEA (carcinoembryonic antigen);
NCA-90 (surface granulocyte non-specific cross-reacting antigen) on neutrophils
murine monoclonal Fab'-SH fragments for conjugation with technetium-99m
Diagnostic imaging of infection/inflammation in bone (suspected osteomyelitis); marketed/approved in European Union
Immunomedics GmbH
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