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WEBbook of Biologic Therapies > Soluble Receptor Constructs

Soluble Receptor Constructs

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Chemical or Common Name Brand Name Other Names Molecular Target Molecular Structure Licensed Indication and/or Major Target Diseases
Manufacturer and/or Distributor
Anakinra
Kineret

Interleukin-1 type I receptor (IL-1RI)
recombinant, nonglycosylated form of the human interleukin-1 receptor antagonist (IL-1Ra)
moderately to severely active rheumatoid arthritis, in patients 18 years of age or older who have failed 1 or more disease modifying antirheumatic drugs
Amgen
Rilonacept
Arcalyst
IL-1 Trap, IL-1 Blocker
IL-1 beta (IL-1β) Dimeric fusion protein; ligand-binding domains of IL-1 receptor (IL-1R) & IL-1 receptor accessory protein (IL-1RAcP) linked to human IgG1 cryopyrin-associated periodic fever syndromes (CAPS), including Muckle-Wells syndrome (MWS) and familial cold autinflammatory syndrome (FCAS) in children 12 years and older
Regeneron
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